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Paschapur, Mahesh S.
- Screening For Wound Healing Activity of Alcoholic Extract of Ocimum kilimandscharicum Leaves
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Authors
Affiliations
1 K.L.E.S's College of Pharmacy, Ankola - 581314, Karnataka, IN
2 KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
1 K.L.E.S's College of Pharmacy, Ankola - 581314, Karnataka, IN
2 KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 93-96Abstract
Objective: To investigate and rationalize the effects of Ocimum kilimandscharicumleaves(Lamiaceae) for their wound healing activity and probable mechanism underlying its protective effects in albino wistar rats.
Methods: The wound healing activity was evaluated using three different types of wound models viz; the excision, incision and dead space wound model. A supportive study was also made on granuloma tissue to estimate the level of hydroxy proline. The healing tissues obtained on the 11th post wounding day of the incision wound model were processed for histological study.
Results: The animals receiving the alcoholic extract of Ocimum kilimandscharicumleaves has shown to possess significant increase in wound closure rate, skin breaking strength, granuloma breaking strength, hydroxy proline content, granuloma dry weight and decrease in mean scar area.
Conclusion: The prohealing potential of the Ocimum kilimandscharicum leaves extract may probably be as a result of the presence of a mixture of phytoconstituents including flavonoids, steroids, etc. and increased collagen deposition as well as better alignment and maturation.
Keywords
Ocimum Kilimandscharicum, Alcoholic Extract, Wound Healing, Hydroxy Proline, Phytochemicals.
References
- Souba WW, Wilmore D: Diet and nutrition in case of the patient with surgery, Trauma and sepsis. In Modern Nutrition in Health and Disease. 9th edition. Edited by: Shils M, Olson J, Shike M, Ross AC. Baltimore, Williams and Wilkins; 1999:1589-1618.
- Ramzi SC, Vinay K and Stanley R .Pathologic Basis of Diseases. WB Saunders Company, Philadelphia. 1994; 5:86.
- Stuart E, Patricia P. Pathophysiology of Healing. 2004; 1st edition: 234
- Charles VM, Rusell RCG, Williams NS. (1995) Short Practice of Surgery, Champan and Hall: London; 9-11.
- Puratchikody A, Nithya Devi C, Nagalakshmi G. Wound healing activity of Cyperus rotundus Linn. Indian J Pharm Sci. 2006; 68(1): 97-101.
- Kweka EJ, Mosha F, Lowassa A, Mahande AM, Kitau J, Matowo J. Ethnobotanical study of some of mosquito repellent plants in north-eastern Tanzania. Malar J. 2008; 7(7): 152.
- Seyoum A, Killeen GF, Kabiru EW, Knols BG, Hassanali A. Field efficacy of thermally expelled or live potted repellent plants against African malaria vectors in western Kenya. Trop Med Int Health. 2003; 8(11): 1005-1011.
- Vaidyaratnam PS. (1994) Varier's Arya Vaidya Sala - Indian Medicinal Plants A Compendium of 500 species, Orient Longman: Chennai; 164-167.
- Lee KH. Studies on the mechanism of action of salicylate. II. Retardation of wound healing by aspirin. J Pharm Sci. 1968; 57: 1042-1043.
- Elrlich HP, Hunt TK. The effects of cortisone and anabolic steroids on the tensile strength of healing wounds. Ann Surg. 1969; 170 (2): 203-206.
- Bonte F, Dumas M, Chaudagne C, Meybeck A. Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis, Planta Med. 1994; 60(2): 133-135.
- Corton S R, Kumar V and Collins T. Robbins Pathologic Basis of Disease, Harcourt Limited, New Delhi (India), Sixth Ed, 2003: 96-111.
- Williams TC and Frohman LA. Potential therapeutic indication for growth hormone releasing hormone in the condition other than growth retardation. Pharmacotherapy. 1986; 6: 311-318.
- Senel O, Cetinkale O, Özbay G, Ahcioglu F and Bulan R. Oxygen free radicals impair wound healing in ischemic rat skin. Ann plast surg. 1997; 39:516-523.
- Rao CM and Ghosh A. Does metronidazole reduce lipid peroxidation in burn injuries. Indian J Pharmacol. 1997; 29: 29-32.
- Manjunath BK, Vidya M, Krishna V, Mankani KL. Wound healing activity of Leucas Hirta. Ind J Pharm Sci. 2006; 5: 380-84.
- Manjunatha KP, Kulkarni GT, Patil GS. Preliminary phytochemical investigation and wound healing activity of the ischolar_mains of Swertia chirata buch. Ham(Gentinaceae). Indian drugs. 2006; 43:535-37.
- Design and Characterization of Albumin-Chitosan Microspheres of Aceclofenac for Sustained Release
Abstract Views :171 |
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Authors
Affiliations
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Science and Technology, Vol 1, No 1 (2009), Pagination: 35-38Abstract
The present study deals with the formulation and characterization of cross linked chitosan/ albumin microspheres containing an NSAID drug Aceclofenac. The microspheres were prepared by suspension cross linking method using gluteraldehyde as a cross linking agent of the polymer matrix. Total eight formulation batches (F1 to F8) were formulated using chitosan/albumin alone and in combinations. The formulations were subjected to various evaluation parameters like % practical yield, entrapment efficiency, particle size distribution, swelling ratio, In vitro release and stability studies. Perfectly spherical cross linked microspheres loaded with aceclofenac were obtained in the size range of 50 - 500 μm. The % practical yield, entrapment efficiency, particle size, swelling ratio were increased with increased concentration of polymer used. The release of aceclofenac was influenced by polymer concentration and size of microspheres. The stability studies of formulation showed 4°C is suitable temperature for storage.Keywords
Cross Linked Microspheres, Controlled Release, Chitosan, Albumin, Aceclofenac.- Formulation and Evaluation of Captopril Fast Dissolving Tablets by WOW Tab and Effervescent Technologies
Abstract Views :158 |
PDF Views:0
Authors
Affiliations
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
1 Dept. of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Dept. of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Dept. of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Science and Technology, Vol 1, No 1 (2009), Pagination: 29-32Abstract
Fast dissolving tablets of Captopril were prepared by Wow tab and Effervescent technologies. In this study our aim was to provide the tablet that quickly disintegrates or dissolves upon contact with saliva and also to provide a good mouth feel. The excipients used in both the technologies not only aid fast disintegration of tablets, but also mask the slight bitter taste of drug. All the prepared formulations were evaluated for thickness, hardness, friability, weight variation, drug content, and disintegration time and drug dissolution. Tablets from Wow tab and Effervescent technologies have shown 94 and 96% of the drug release at the end of 10 min respectively. Study has shown that 8:6 ratio of sodium bicarbonate and citric acid in the Captopril fast dissolving tablets gave good soothing and excellent mouth feel. Tablet prepared by Wow tab technology, formulation W5 and W6 using low moldability saccharide (lactose and mannitol) showed rapid disintegration and released about 92 and 96% drug respectively. Study concluded that fast dissolving tablets of Captopril could be prepared successfully by above mentioned methods. Tablets imparted patient benefits and increased consumer satisfaction, despite the different mechanisms involved in these techniques.Keywords
Fast-Dissolving Tablets, Captopril, ACE Inhibitor, Oral Cavity, In vitro Dissolution.- Isolation and Evaluation of Anacardium occidentale Gum as a Binding Agent in Tablet Formulations
Abstract Views :208 |
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Authors
Affiliations
1 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, IN
2 Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola- 581314, IN
1 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola-581314, IN
2 Principal KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
3 Department of Pharmaceutics, K.L.E.S's College of Pharmacy, Ankola- 581314, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 150-157Abstract
Plant products serve as an alternative to synthetic products because of local accessibility, eco-friendly nature and lower prices compared to imported synthetic products. Natural gums and mucilage have been widely explored as pharmaceutical excipients. Mucilage extracted from Anacardium occidentale (Ao) were subjected to toxicity studies for its safety and preformulation studies for its suitability as a binding agent. The present study was undertaken with an objective to find out the binding potentials of a natural gum obtained from plant Anacardium occidentale. Physicochemical characteristics of mucilage, such as solubility, swelling index, loss on drying, and pH were studied and also microbial load was determined. The mucilage was evaluated for its granulating and binding properties in tablets, using Diclofenac as a model drug. Properties of the granules prepared with diclofenac using five different concentrations (2, 4, 6, 8 and 10% w/v) of Ao mucilage and compared with starch (10%, w/v), as standard binder. The prepared granules were evaluated for percentage of fines, average particle size, total porosity, compressibility index and flow properties. The tablets were prepared and evaluated for content uniformity, hardness, friability, disintegration time and in vitro dissolution profiles. The tablets had good physicochemical properties, and the drug release was more than 90% within 90 min. The tablets prepared by using 10% mucilage as binder exhibited more hardness than by using 2, 4 and 8% concentration. At 6% concentration it has given similar disintegration time and dissolution profile in comparison to starch at 10 % w/v. Hence, Ao mucilage at 6% w/v concentrations can be considered as ideal concentrations for preparation of tablets.Keywords
Anacardium Occidentale Mucilage, Binding, Tablets, Diclofenac, Swelling Index.- Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats
Abstract Views :162 |
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Authors
Affiliations
1 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
3 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
1 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
2 Department of Pharmacognosy, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
3 Department of Pharmaceutics, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
4 Department of Pharmacology, K.L.E.S’s College of Pharmacy, Ankola-581314, Karnataka, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 59-63Abstract
Objective: The present study is designed to investigate anti-inflammatory activities of ethanolic extract of male flowers (inflorescences) of Borassus flabellifer L. (Arecaceae).
Methods: Acute inflammation models like histamine-induced and eggalbumin- induced rat paw edema model and xylene induced ear oedema in mice were employed to investigate the anti-inflammatory activity. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), lipid per oxidation and alkaline phosphatase (ALP) were also estimated as supportive study.
Results: The extract at doses 150mg/kg b.w. and 300mg/kg b.w. and diclofenac sodium (standard) showed significant anti-inflammatory in all the models, as compared to control (p< 0.0001). The extract and standard drug also showed significant (p<0.0001) results for biochemical parameters.
Conclusion: The results of the present further confirm the use of Borassus flabellifer L. traditionally for the treatment of painful inflammatory conditions.